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Men-Tsee-Khang (the Tibetan Medical and Astrological Institute) was established on March 23rd, 1961, with Dr. Yeshi Dhonden and Ven. Lodoe Gyatso as the heads of the Medical and Astrological sections, respectively.

Initially, Men-Tsee-Khang lacked necessary facilities, money, and staff, and was situated in a room on the upper floor of an old house in Mcleod Ganj, Dharamsala, in Himachal Pradesh. Mcleod Ganj is a small town known as "Little Lhasa", situated at the base of the Dhauladhar mountains at 1768 meters above main sea level. At present, the Institute's headquarters in Dharamsala oversees the operation of 48 branch clinics in India, Nepal and three residential doctors abroad.

Since beginning operations in exile, the work of Men-Tsee-Khang has undergone significant development with the creation of the Pharmaceutical, Research & Development, Materia Medica, Editoral & Publication, Medical & Astro. College for training new doctors and astrologers, Herbal Product Research department, Medicine Stores, and Accounts.

Men-Tsee-Khang has a dispensary, an in-patient unit and a surgical ward for the patients from all over the world. Along with Tibetan refugees, non-Tibetans from nearby areas and patients from all over the world are treated here.